Lower Bounds for Graph-Walking Automata

Graph-walking automata (GWA) traverse graphs by moving between the nodes following the edges, using a finite-state control to decide where to go next. It is known that every GWA can be transformed to a GWA that halts on every input, to a GWA returning to the initial node in order to accept, as well as to a reversible GWA. This paper establishes lower bounds on the state blow-up of these transformations: it is shown that making an n-state GWA traversing k-ary graphs return to the initial node requires at least 2(n-1)(k-3) states in the worst case; the same lower bound holds for the transformation to halting automata. Automata satisfying both properties at once must have at least 4(n-1)(k-3) states. A reversible automaton must have at least 4(n-1)(k-3)-1 states. These bounds are asymptotically tight to the upper bounds proved using the methods from the literature

Contemporary Issues of Commercial Invertebrates’ Harvesting in the Russian Sector of the Barents Sea

The Russian fishery for invertebrate hydrobionts in the Barents Sea includes the list of a dozen species of crustaceans, mollusks, and echinoderms. This type of fishery is characterized by great diversity in relation to the status of exploited stocks, catch size, and economic efficiency of the fishery. The list of up-to-date problems of this industry is long and includes biological, scientific, commercial, socio-economical, and market issues. Among the main problems of the Russian invertebrate fishery in the Barents Sea, overfishing, underutilization of a number of stocks, and significant emissions from fishing waste are considered. The causes of these problems, possible solutions and the priorities of such a solution are analyzed

Marketing aspects of sustainable urban development in small towns of the Republic of Tatarstan

The article describes the concept of sustainable development and forms the criteria for sustainable development of the territory. The sustainability of the territory development should be considered from various angles, including industrial and agricultural development, the level of environmental friendliness, intersectoral and interdimensional interaction, creating the attractiveness of territories. The solution to the problems of territories attractiveness is to be found in the field of territorial marketing. The city as the pinnacle of territorial marketing requires a detailed analysis of the current state and the development of a strategy for further development. The scientific work describes an algorithm for the formation of marketing strategies for urban development. The research provides analysis of small towns development in the Republic of Tatarstan: Almetyevsk, Bolgar, Nizhnekamsk. Developing marketing strategies designed to enhance the attractiveness of small towns are identified as one of the backgrounds for creating comfortable conditions for residents and attracting tourists and professionals to improve the efficiency of the towns' resources. At the same time, it is of vital importance to analyze the internal components of the towns, pull factors for residents and tourists to form the most appropriate marketing strategy for urban development. Small towns, in contrast to megacities, have great creative and cultural potential, which allows them to find new points of attraction on their territory and strengthen the existing tourist and infrastructure facilities

Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 9th edition

Dear Colleagues! We are glad to present the 9th Edition (revised) of Standards of Diabetes Care. These evidence-based guidelines were designed to standardize and facilitate diabetes care in all regions of the Russian Federation. The Standards are updated on the regular basis to incorporate new data and relevant recommendations from national and international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013), International Diabetes Federation (IDF, 2011, 2012, 2013), American Diabetes Association (ADA, 2018, 2019), American Association of Clinical Endocrinologists (AACE, 2019), International Society for Pediatric and Adolescent Diabetes (ISPAD, 2014, 2018) and Russian Association of Endocrinologists (RAE, 2011, 2012, 2015). Current edition of the “Standards” also integrates results of completed randomized clinical trials (ADVANCE, ACCORD, VADT, UKPDS, SAVOR, TECOS, LEADER, EXAMINE, ELIXA, SUSTAIN, DEVOTE, EMPA-REG OUTCOME, CANVAS, DECLARE, CARMELINA, REWIND, etc.), as well as findings from the national studies of diabetes mellitus (DM), conducted in close partnership with a number of Russian hospitals. Latest data indicates that prevalence of DM in the world increased during the last decade more than two-fold, reaching some 463 million patients by the end of 2019. According to the current estimation by the International Diabetes Federation, 578 million patients will be suffering from diabetes mellitus by by 2030 and 700 million by 2045. Like many other countries, Russian Federation experiences a sharp rise in the prevalence of DM. According to Russian Federal Diabetes Register, there are at least 4 584 575 patients with DM in this country by the end of 2018 (3,1% of population) with 92% (4 238 503) – Type 2 DM, 6% (256 202) – Type 1 DM and 2% (89 870) – other types of DM, including 8 006 women with gestational DM. However, these results underestimates real quantity of patients, because they consider only registered cases. Results of Russian epidemiological study (NATION) con- firmed that only 54% of Type 2 DM are diagnosed. So real number of patients with DM in Russia is 9 million patients (about 6% of population). This is a great long-term problem, because a lot of patients are not diagnosed, so they don’t receive any treatment ant have high risk of vascular complications. Severe consequences of the global pandemics of DM include its vascular complications: nephropathy, retinopathy, coronary, cerebral, coronary and peripheral vascular disease. These conditions are responsible for the majority of cases of diabetes-related disability and death. In сurrent edition of the “Standards”: New goals of glycemic control for the elderly, based on the presence of functional dependence, as well as for pregnant women, children and adolescents, are given. Added a snippet that describes the continuous glucose monitoring. Only low-density lipoprotein cholesterol level is used as a target for lipid metabolism. Proposes more stringent target levels of blood pressure. It also features updated guidelines on stratification of treatment in newly diagnosed Type 2 diabetes: the excess of the initial level of HbA1c over the target level was used as a criterion. In the recommendations for the personalization of the choice of antidiabetic agents, it is taken into account that in certain clinical situations (the presence of atherosclerotic cardiovascular diseases and their risk factors, chronic heart failure, chronic kidney disease, obesity, the risk of hypoglycemia) certain classes of hypoglycemic agents (or individual drugs) have proven advantages. Recommendations for psychosocial support are added. The position of metabolic surgery as a method of treatment of DM with morbid obesity is updated. Recommendations for diagnostic and treatment of hypogonadism syndrome in men with DM are added. For the first time, evidence levels of confidence and credibility levels of recommendations for diagnostic, therapeutic, rehabilitative and preventive interventions based on a systematic review of the literature are given in accordance with the recommendations of the Center for Healthcare Quality Assessment and Control of the Ministry of Health of the Russian Federation. This text represents a consensus by the absolute majority of national experts, achieved through a number of fruitful discus- sions held at national meetings and forums. These guidelines are intended for endocrinologists, primary care physicians and other medical professionals involved in the treatment of DM. On behalf of the Working Grou

Standards of specialized diabetes care. Edited by Dedov I.I., Shestakova M.V., Mayorov A.Yu. 10th edition

Dear Colleagues!We are glad to present the 10th Edition (revised) of the Standards of Specialized Diabetes Care. These evidence-based guidelines were designed to standardize and facilitate diabetes care in all regions of the Russian Federation.The Standards are updated on the regular basis to incorporate new data and relevant recommendations from national and international clinical societies, including World Health Organization Guidelines (WHO, 2011, 2013), International Diabetes Federation (IDF, 2011, 2012, 2013), European Association for the Study of Diabetes (EASD 2018, 2019), American Diabetes Association (ADA, 2018, 2019, 2021), American Association of Clinical Endocrinologists (AACE, 2020, 2021), International Society for Pediatric and Adolescent Diabetes (ISPAD, 2018) and Russian Association of Endocrinologists (RAE, 2019). Current edition of the “Standards” also integrates results of completed randomized clinical trials (ADVANCE, ACCORD, VADT, UKPDS, SAVOR, TECOS, LEADER, EXAMINE, ELIXA, SUSTAIN, DEVOTE, EMPA-REG OUTCOME, CANVAS, DECLARE, CARMELINA, REWIND, CREDENCE, CAROLINA, DAPA-CKD, DAPA-HF, EMPEROR-Reduced trial, VERIFY, VERTIS CV, PIONEER, etc.), as well as findings from the national studies of diabetes mellitus (DM), conducted in close partnership with a number of Russian hospitals.Latest data indicates that prevalence of DM in the world increased during the last decade more than two-fold, reaching some 537 million patients by the end of 2021. According to the current estimation by the International Diabetes Federation, 643 million patients will be suffering from DM by 2030 and 784 million by 2045.Like many other countries, Russian Federation experiences a sharp rise in the prevalence of DM. According to Russian Federal Diabetes Register, there are at least 4 871 863 patients with DM in this country on 01.01.2021 (3,34% of population) with 92,3% (4 498 826)–Type 2 DM, 5,6% (271 468)–Type 1 DM and 2,1% (101 569)–other types of DM, including 9 729 women with gestational DM. However, these results underestimates real quantity of patients, because they consider only registered cases. Results of Russian epidemiological study (NATION) confirmed that only 54% of Type 2 DM are diagnosed. So real number of patients with DM in Russia is 10 million patients (about 7% of population). This is a great long-term problem, because a lot of patients are not diagnosed, so they don’t receive any treatment and have high risk of vascular complications.Severe consequences of the global pandemic of DM include its vascular complications: nephropathy, retinopathy, coronary, cerebral and peripheral vascular disease. These conditions are responsible for the majority of cases of diabetes-related disability and death.In сurrent edition of the “Standards”:New goals of glycemic control for continuous glucose monitoring (time in range, below range and above range, glucose variability) are given.It also features updated guidelines on stratification of treatment in newly diagnosed Type 2 diabetes.In the recommendations for the personalization of the choice of antidiabetic agents, it is taken into account that in certain clinical situations (the presence of atherosclerotic cardiovascular diseases and their risk factors, chronic heart failure, chronic kidney disease, obesity, the risk of hypoglycemia) certain classes of hypoglycemic agents (or individual drugs) have proven advantages.Indications for the use of antidiabetic agents in chronic kidney disease are expanded.Information about insulin pump therapy is added.Recommendations on vaccination are added.An algorithm for replacing some insulin preparations with others is given.This text represents a consensus by the absolute majority of national experts, achieved through a number of fruitful discussions held at national meetings and forums. These guidelines are intended for endocrinologists, primary care physicians, pediatricians and other medical professionals involved in the treatment of DM.Compared with previous edition of the Standards of Specialized Diabetes Care edited by Dedov I.I., Shestakova M.V., ­Mayorov A.Yu., 10th edition, Moscow, 2021 (signed for printing on 10.09.2021) a number of changes have been made.On behalf of the Working Grou

Diabetes mellitus type 2 in adults

Public organization “Russian Association of Endocrinologists”. Clinical guidelines.&nbsp

Diabetes mellitus type 1 in adults

Public organization “Russian Association of Endocrinologists”. Clinical guidlines

Comparing the Effectiveness of Outdoor Advertising with Internet Advertising : Case Study: Inetcom Company

At the time of rapid changes, it might appear that some aspects of the pre-online life are vanishing. However, they have only mutated into new fascinating forms which arguably prove to be more effective and usable by tech-savvy population. In the marketing world, numerous techniques, including both traditional and non-traditional media, are used to attract and retain consumers. The purpose of this study was to identify the effectiveness of the case company’s advertising methods, namely, outdoor advertising and internet advertising, and then justify outdoor advertising as the most effective marketing method in the company. The study results were found to be important as they would influence the profitability of the organization based on avoiding ineffective advertising methods. The study was implemented by conducting theoretical research and then analyzing the data provided by the case company. The research design was that of the mixed approach: both qualitative and quantative methods were applied. The quantitative approach was used to obtain numerical data from the respondents based on the following categories: demographic, age, marital status and level of education. The qualitative approach was used to obtain information about the participants’ personal responses or authors’ observations in the field. The results of the study showed that despite the popularity of advertising on the Internet, it was often associated with fraud and should not be considered as reliable as outdoor advertising. Outdoor advertising was identified as a facilitator of acquiring accurate access to data and elongating the advertising period at the same station. Based on the research findings, the case company was advised to focus on outdoor advertising rather than on Internet advertising